University of Oxford researchers who used PET with the translocator protein-targeting carbon-11 PBR28 tracer found that individuals with rheumatoid arthritis had significantly higher tracer signaling in their joints and had nearly tenfold higher hydrogen-3 PBR28-specific binding in the joint lining tissue, compared with healthy controls. The findings in the Journal of Nuclear Medicine suggest that "TSPO PET likely acts as an imaging tool of not only macrophages but also activated synovial fibroblasts, a cell group increasingly recognized to play a critical role in RA inflammation," lead author Nehal Narayan said.
PET with C-11-based tracer may help assess rheumatoid arthritis
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