Family history of Parkinson's disease or dementia, depression, excessive daytime somnolence, earlier menarche and epilepsy had increased odds of Parkinson's, but abstaining from smoking and low alcohol intake were protective factors, and individuals with elevated polygenic risk scores had 3.4 times higher Parkinson's risk and an earlier age of Parkinson's onset, while diabetes was a stronger risk factor among those with low genetic Parkinson's risk, according to a study in the Journal of Neurology, Neurosurgery & Psychiatry. The findings "provide further evidence that we can identify a group at higher risk of Parkinson's disease, who would be ideal candidates for neuroprotective drug trials or other prevention strategies," researcher Dr. Alastair Noyce said.
Parkinson's disease risk factors highlighted in study
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