Researchers found that people with progressive supra-nuclear palsy or Pick's disease associated with tau accumulation had 50% lower levels of the vacuolar protein sorting 35 molecule in their brain tissue, compared with those without neurodegenerative disease, and altering VPS35 levels in cultured human cells allowed direct tau buildup regulation. The findings in Molecular Psychiatry also associated lower VPS35 to worse memory and 40% to 50% reduced synaptic connectivity in mice with tau deposits.
Study IDs mechanism that may control tau accumulation
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