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PET/CT measures may foretell Richter syndrome in CLL

Researchers found that maximum standardized uptake value body weight, body surface area, lean body mass, lesion-to-liver SUV ratio and lesion-to-blood SUV ratio on F-18 FDG-PET/CT scans were significantly tied to odds of Richter syndrome among patients with chronic lymphocytic leukemia, with the SUVmax value of 9 being the best threshold for foretelling CLL-related Richter syndrome risk by SUVbw. The findings in the journal Clinical Lymphoma Myeloma and Leukemia also showed that those with CLL and Richter syndrome had significantly shorter median overall survival than those with CLL alone, with all PET/CT parameters, along with B symptoms and Binet stage being significantly linked to OS.

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