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Study sheds light on varying damage caused by Alzheimer's-linked genes

People with Alzheimer's disease who had mutations in the APP, PSEN1 and PSEN2 genes, which are associated with inherited Alzheimer's, had more astrocytes and fewer neurons compared with those with Alzheimer's who didn't have the genetic mutations, researchers at Washington University School of Medicine in St. Louis reported in Genome Medicine. The findings also showed increased astrocytes and reduced neurons among those with APOE4, while those with TREM2 mutation had glial cell damage but less significant neuronal loss.

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