Nineteen percent of older adults with dementia had quadruple misfolded proteins, or amyloid-beta, alpha-synuclein, tau and TDP-43 protein accumulation, a faster progression from mild cognitive impairment to dementia, and the most severe dementia symptoms, compared with patients with three or fewer pathologies, according to a study in JAMA Neurology. The findings suggest the increased prevalence of this more complex dementia type and the greater diversity of cognitive decline-related diseases, researchers wrote.
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