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Exercise may trigger Alzheimer's-protecting hormone

Researchers found that individuals with Alzheimer's had lower levels of the hormone irisin in the hippocampus, and mouse models with Alzheimer's disease that swam almost daily for five weeks had elevated irisin and didn't develop cognitive impairment, but those that received irisin-blocking drugs had similar memory performance as those that were sedentary. The findings in Nature Medicine suggest that irisin may have a protective role in Alzheimer's and could prompt the development of a breakthrough therapy for dementia prevention and treatment, said researcher Dr. Ottavio Arancio.

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