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PET study links sleep apnea to increased Alzheimer's disease risk

Researchers examined spinal fluid and amyloid PET scans from 208 individuals ages 55 to 90 with normal cognition and found that those with obstructive sleep apnea had increased amyloid plaque accumulation associated with Alzheimer's disease in proportion to OSA severity, compared with those without OSA, but OSA severity didn't correlate with mental decline. The findings in the American Journal of Respiratory and Critical Care Medicine suggest a nonlinear link between amyloid burden and cognition, said researcher Dr. Andrew Varga, while researcher Dr. Ricardo Osorio suggested that treating OSA may reduce amyloid burden and Alzheimer's risk among the elderly.

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