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Cancer vaccine safe, effective in animals

A cancer vaccine that inhibits expression of immune cells' checkpoint proteins will be tested in people after research in animals showed it is safe and effective when combined with an immunotherapy drug. The vaccine activates both B- and T-cell functions to promote tumor clearance and blocks signaling pathways that enable tumor growth, says researcher Pravin Kaumaya, and the combination therapy produced a complete response in nine of 10 animal models of colon cancer.

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