A gene therapy that sparks expression of brain-derived neurotrophic factor and its receptor, tropomyosin receptor kinase B, reversed glaucoma and misfolded tau proteins in mouse models, researchers reported in Science Advances. The molecules promote axonal transport of materials between cells, and disrupting the process causes neurodegenerative disease, but the therapy repairs the transport network, says first author Tasneem Khatib.
Gene therapy reverses glaucoma, misfolded tau in mice
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