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Study finds mutation that might make anesthesia riskier for some dogs

In a study published in Scientific Reports, researchers identified a genetic mutation common in greyhounds and related breeds that prevents the breakdown of anesthetics such as midazolam, ketamine and propofol. After analyzing donated samples from the Washington State University Veterinary Teaching Hospital DNA Bank, the researchers also discovered that about 1 in 50 golden retrievers, 1 in 300 Labrador retrievers and a smaller proportion of other breeds may also have the mutation, which reduces production of CYP2B11 enzymes, and they hope to help develop a simple test for the mutation.

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