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Monkey embryos enable study of HIV gene therapy

A man was cured of HIV when he received a bone marrow transplant from someone with a nonfunctional CCR5 gene, and another was cured by a stem cell transplant with the same mutation, which occurs in less than 1% of the population. Now, scientists at the University of Wisconsin have developed a monkey model of the mutation using CRISPR technology to edit cynomolgus macaque monkey embryos, giving researchers a reliable way to study CCR5 gene therapy in monkeys with simian immunodeficiency virus.

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