Injecting interleukin-4 reduced pain for up to eight days in mouse models of sciatic nerve pain by encouraging macrophages to produce opioid peptides at the site of inflammation, according to a study in the Journal of Clinical Investigation Insight. The findings could help researchers develop treatments for a number of immune-mediated diseases, including arthritis, neurodegenerative diseases and cancer, says study leader Halina Machelska.
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