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Researchers ID genes linked to rare canine blood cancer

Scientists studying Bernese mountain dogs, Rottweilers, and flat-coated and golden retrievers confirmed a link between CDKN2A gene mutations in histiocytic sarcoma and identified four more loci associated with not only the rare blood cancer but also lymphoma and mast cell tumors. The breeds are predisposed to histiocytic sarcoma, which also affects people, and the study, published in PLOS Genetics, shows that dogs "provide efficient natural models to identify the genetics underlying several dog-human homologous cancers."

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