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10/23/2020

The FDA plans to use its Sentinel system to track COVID-19 vaccine adverse events, and the CDC also plans to use existing data collection platforms, but a lack of both data standards and interoperability will complicate efforts to track COVID-19 vaccine safety and side effects, experts say. A patient registry would augment EHR and claims data, and would facilitate outcomes and efficacy comparisons, says Nancy Dreyer, IQVIA's chief scientific officer.

10/23/2020

A study in the Annals of Emergency Medicine found that combining point-of-care ultrasound findings and clinical COVID-19 symptoms yielded 95% sensitivity and specificity, as well as 100% accuracy, in determining individuals with COVID-19 who had false-negative reverse-transcription polymerase chain reaction test results. However, researchers stressed that sonographic and clinical findings should accompany, not replace, the use of RT-PCR testing in COVID-19 diagnosis.

10/23/2020

A study in JAMA Oncology found that individuals with brain metastases who underwent postoperative hypofractionated stereotactic radiotherapy had 65% one-year overall survival and 94% local control at five months, while 13.1% had leptomeningeal disease and 8.6% had radiation necrosis. "Although the study ... on multivariable analysis did not identify a correlation of outcomes with volume or histologic subtype, these findings highlight the need to address whether hypofractionation schedules may be better suited for particular histologic subtypes or target volume sizes," according to an accompanying editorial.

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SRT
10/23/2020

Consumption of alcohol has increased during the pandemic, and some people may find they're using it as a coping mechanism as normal ways of life have been upended, says licensed clinical social worker Barbara Rexer. "Finding small ways to recapture a feeling of normalcy and connection with others is an important part of managing not just addiction, but the ongoing stress of the pandemic," Rexer says.

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Forbes
10/23/2020

A panel of vaccine experts told the FDA to ensure it collects robust safety data to bolster public trust before granting emergency use authorization to any COVID-19 vaccine, and the agency said it will consult with the panel before granting an EUA.

10/23/2020

Metabolic management for one year improved thyroid function, blood glucose levels and insulin resistance in patients with poorly controlled diabetes, according to a study in the Journal of Diabetes. The research was based on 2,000 participants in China.

10/23/2020

Flash glucose monitoring can increase the time within target range for blood glucose levels among patients with type 2 diabetes on sulfonylurea or insulin treatment who experienced acute coronary syndrome, compared with self-monitoring of blood glucose. The findings, presented at the European Association for the Study of Diabetes virtual meeting, also revealed that flash glucose monitoring shortens the time spent in hypoglycemia, compared with SMBG.

10/23/2020

A study in the European Journal of Gastroenterology & Hepatology found that patients with acute diverticulitis and diabetes had a higher rate of diverticular bleeding, but lower rate of colectomy, abscess and obstruction, compared with patients with acute diverticulitis without diabetes. The findings also revealed that complicated diabetes coexisting with acute diverticulitis was not tied to higher mortality rates or diverticulitis-related complications, compared with uncomplicated diabetes.

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Medical Dialogues
10/23/2020

Former Microsoft executive Terry Myerson on Thursday introduced his startup Truveta, which will work on data innovations to improve patient care. Myerson said the company would focus on data privacy, and regulatory filings link it to Providence Health & Services, which has a $300 million venture capital fund for early and mid-stage companies.

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GeekWire
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Terry Myerson
10/23/2020

Community Health Network, Eskenazi Health and Indiana University Health declared racism a public health crisis and pledged to create a "culture of inclusion" and work to reduce health disparities and inequity. Leaders of the three systems said their boards were diverse but they would add members from the Black, Latino and Native communities.