Nearly 7% of almost 495,000 radiologic exam orders across seven imaging modalities went unscheduled in a hospital EHR one or more months after the exams were originally ordered, most of which were clinically necessary, according to a study in the Journal of the American College of Radiology. The high prevalence of unscheduled orders may delay diagnosis and prompt unneeded radiation and possible medical errors, and radiologists should implement decision support duplication, workflows ensuring unnecessary orders are canceled and computerized monitoring systems, as well as address factors boosting radiologic exam order adherence among patients and remain vigilant on exams outside the system, researchers wrote.
Researchers found no improvement in the interrater reliability of tibial tubercle-trochlear groove distance measurements on MRI among patients with patellar instability when MRI slices are preselected for measuring, compared with independent selection of slices. The study in the Journal of ISAKOS found that only sulcus angle measurements showed a significant improvement of interrater reliability from preselection of slices.
All of the first 41 patients with confirmed novel coronavirus in Wuhan, China, had chest CT scan abnormalities suggesting pneumonia, and bilateral involvement was found in 98% of the cases, while about 30% had acute respiratory distress syndrome, researchers reported in The Lancet. Another study in the same journal detailed the person-to-person spread of the 2019-nCoV among a family who traveled to Wuhan, which also affected a family member who didn't travel to the region, and all of the infected people had chest CT scans with ground-glass opacities, and those older than 60 had more considerable radiological alterations.
A tool based on patient's age, sex, cognitive performance and comorbidity status yielded "good accuracy" in predicting the life expectancy of individuals with dementia, researchers reported in the journal Neurology. The findings also showed increased mortality risk among older patients, males, those with non-Alzheimer's dementia, those with reduced cognition and higher comorbidity burden at diagnosis, those who lived alone and those with higher medication use.
A study in the journal Thyroid found that adults who underwent radiotherapy in childhood and later developed thyroid cancer had similar mortality risk, compared with those who didn't develop thyroid cancer, even when including only those with tumors at least 10 mm in size. The findings "indicate that radiation-induced thyroid cancer does not negatively affect overall survival," researchers wrote.
A new AI-based blood sample analysis tool was presented in a study in the Journal of Digital Imaging as a potential low-cost method of detecting malaria. The model, which can be used with simple mobile devices, is capable of processing each image in milliseconds and when tested using two data sets, achieved 99.07% and 97.46% accuracy.
Rats with late preclinical stage Alzheimer's disease that received lithium at doses up to 400 times lower than current mood disorder prescriptions had reduced Alzheimer's pathology and better cognition, according to a study in the Journal of Alzheimer's Disease. The findings suggest that a microdose lithium formulation, which facilitates brain entry while minimizing lithium-related adverse events, "should find immediate therapeutic applications," said researcher Dr. Claudio Cuello.
Sanofi has completed its acquisition of Synthorx worth an estimated $2.5 billion. The immuno-oncology specialist's lead candidate THOR-707, a drug being developed for solid tumors, is currently being tested in an early-stage trial.
Municipalities across the US have conducted a Point-in-Time count of homeless people in their areas, with the resulting data being used to fund initiatives related to homelessness. Social workers were among those conducting the annual count, handing out gift cards for food, directing people to resources and distributing supplies.
Pediatricians should determine children and adolescents who have a high risk of running away or being thrown out of their homes and offer them and their families early intervention aimed at modifiable risk factors, according to an American Academy of Pediatrics clinical report in Pediatrics. The report also includes guidance on counseling LGBTQ youths, those who experienced abuse or neglect, those in protective custody and those with substance use and/or mental health problems; recommends assessing mental health, sexual and reproductive health, and trauma exposure among those who have run away; and suggests referrals to resilience-building programs for at-risk and runaway youths.