A Phase II clinical trial in The Lancet Haematology found a 95% response rate among patients with relapsed or refractory multiple myeloma who received double chimeric antigen receptor T-cell therapy with anti-CD19 and anti-B-cell maturation antigens. The rate of complete response was 43%.
Use of the IRON Deficiency in Pregnancy with Maternal Iron Optimization, or IRON MOM, toolkit was associated with a reduction in anemia risk as well as the need for transfusions to treat anemia before and after pregnancy, according to a study in the journal PLOS Medicine. The use of ferritin testing to screen for iron deficiency increased 10-fold with adoption of the paper-based toolkit.
The government of Switzerland will donate $102 million to health agencies of the United Nations to support efforts to address malaria, AIDS and tuberculosis.
A study in the journal Clinical Gastroenterology and Hepatology found that a history of military combat service and being injured during combat were associated with increased risk of exposure to the hepatitis B virus. The findings were based on data from tests of 1,146 samples from military veterans, of whom 43.3% reported combat experience and 10.6% reported exposure to blood during combat.
A study in the journal Clinical Infectious Diseases
outlines challenges faced by hospitals in preparing to identify and treat cases of Ebola virus infection. Potential stumbling blocks include selection of personal protective equipment, complicated protocols for taking off personal protective equipment and financial costs of preparation.
Researchers examined data from the All Babies in Southeast Sweden study and found that among 403 children, those who were at high genetic risk for type 1 diabetes had different gut microbiomes and different gut microbiota composition, compared with those at low genetic risk. The findings, published in Nature Communications, also showed that those who had low or no genetic risk had certain bacterial species that were not found in high-risk children.
Singapore-based molecular diagnostic group Nova Satra has merged with Inex Innovations Exchange to form Inex Innovate, with the goal of providing more accurate diagnostic tests and health care solutions for Asian women. The combined firm will develop the OvaCis detection kit for quick diagnosis of ovarian cysts and aims to develop a blood test for early ovarian cancer detection as well as the first epigenetics-based test for early detection of breast cancer in Asian women.
Three years after being recognized as measles-free by the World Health Organization, the UK has lost the designation and 231 confirmed cases were reported in the first three months of 2019. Immunization rates are falling, with 87% of children in England receiving their second MMR vaccination.
Moderna announced that the FDA has granted Fast Track status to its investigational Zika virus vaccine mRNA-1893. The vaccine is being tested in an early-stage study focused on preventing mother-to-child transmission of the disease.
iBio has entered an agreement with Lung Biotechnology PBC, a unit of United Therapeutics, for the production of a bioink using recombinant human collagen for bioprinting 3D organ transplants. No financial terms of the deal were disclosed.
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