People who may have been exposed to the Ebola virus have been difficult for health workers to contact in the conflict-torn city of Beni in the Democratic Republic of Congo. "We anticipate that now we'll be looking at least another 3-4 months in order to really stem this outbreak, with a strong focus in Beni and surrounding areas," said World Health Organization emergency response chief Dr. Peter Salama.
Tandem autologous/allogeneic hematopoietic cell transplantation was associated with long-term remission of multiple myeloma for certain patients, according to a study in the journal Haematologica. The study, based on data for 244 patients, found a 10-year overall survival rate of 41% and a 10-year progression-free survival rate of 19%.
India has reported 32 confirmed cases of Zika virus infection in Jaipur. Control and containment operations are underway, and samples are being collected for testing from residents in a 3-kilometer radius of the location of the first reported case.
The recent initial public offering of Allogene Therapeutics raised roughly $300 million. The funds will be used to advance off-the-shelf chimeric antigen receptor T-cell therapies using allogeneic T-cells.
The California Institute for Regenerative Medicine has $144 million remaining from the $3 billion it received in a 2004 ballot initiative. CIRM executives are seeking to raise $200 million privately and hoping to put a $5 billion bond measure on the state's November 2020 ballot.
UK-based Orchard Therapeutics said it will build a stem cell production facility in San Francisco using proceeds from a planned initial public offering.
The early-stage study of RNA destabilizer AB-452 as a hepatitis B virus treatment candidate has been delayed by Arbutus Biopharma. The company said more time is needed to characterize the compound.
A prospective study showed Veracyte's Envisia Genomic Classifier demonstrated 70% sensitivity and 88% specificity in detecting usual interstitial pneumonia, which is the basis for idiopathic pulmonary fibrosis diagnosis. The study, which involved 49 patients who had new-onset interstitial lung disease, also showed that in samples with low diagnostic confidence in high-resolution computed tomography images, the test's sensitivity increased to 76%.
Symmetric dimethylarginine has shown potential as an endogenous biomarker of kidney function in veterinary medicine and "commercial availability of an automated assay for SDMA is a high priority for the field," writes Joe El-Khoury, assistant professor of laboratory medicine at Yale School of Medicine. "On the clinical side, it is important to investigate the non-renal factors that affect SDMA levels that may confound interpretation of results," he notes.
Gemelli Biotech and Cedars-Sinai Medical Center introduced a blood test that can detect irritable bowel syndrome at the American College of Gastroenterology Annual Scientific Meeting. IBS Smart diagnoses the disease by examining levels of the biomarkers anti-vinculin and anti-CdtB.
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