Clinical laboratories can take several steps to ensure accurate results for insulin-like growth factor-1 and IGF-binding protein-3 tests. These include monitoring long-term assay performance, participating in external quality assessment programs, letting physicians know which assay is being used and providing clinicians with a detailed reference interval to assist with test result interpretation.
Long-term survival was better among patients with scleroderma who underwent hematopoietic stem cell transplantation than for those who were treated with cyclophosphamide in the 75-patient Scleroderma Cyclophosphamide or Transplantation trial. Survival at 11 years was 88% for those who received HSCT compared with 53% for those treated with cyclophosphamide, and the transplant group also had fewer cases of organ failure, researchers reported at a meeting of the American College of Rheumatology.
The Parker Institute for Cancer Immunotherapy will collaborate with Xyphos Biosciences to develop chimeric antigen receptor T-cell therapies that can be activated by bispecific antibodies.
Canadian geneticist and stem cell researcher Bill Stanford has been testing an investigative treatment for acute myeloid leukemia in mouse models, publishing his team's findings in the journal Cancer Discovery. Stanford hopes to take existing drugs that block the MDM2 gene into clinical trials.
A study of more than 1,000 HIV-positive former inmates in the journal PLOS Medicine found that less than 50% continued to receive treatment three years after release. The rate of continuous care declined to 42.5% after three years, and people who were later sent back to prison had higher rates of care.
An attack by rebels in the Democratic Republic of Congo is slowing efforts to contain the Ebola virus in the city of Beni, according to Peter Salama of the World Health Organization. The rate of new cases doubled after containment efforts were halted by an attack last month.
Since Aug. 1, at least 223 confirmed cases of Ebola have been documented in an outbreak of the virus in the Democratic Republic of Congo, and at least 144 people have died. Public health workers have struggled in some cases to implement preventive measures, and researchers are especially concerned about a disproportionate number of infections seen in children, who accounted for 60% of newly reported cases in the first two weeks of October around the current epicenter of disease.
A retraction was issued by the New England Journal of Medicine for a 2011 paper titled "Evidence for Human Lung Stem Cells," co-authored by Dr. Piero Anversa, cardiac stem cell proponent and former Harvard University professor, and the journal also published an "expression of concern" concerning two other studies. The retraction was made because of evidence that some images included in the paper had been manipulated.
The devastating effects of Zika virus are becoming evident as those born with related defects in Brazil grow older, and now more cases of microcephaly are surfacing among infants in Angola. The data emphasize the need for funding for continuous surveillance, monitoring and prevention of the disease, as well as the need for improved diagnostics and birth defect monitoring programs.
The World Health Organization declared that the Democratic Republic of Congo's current Ebola outbreak does not constitute a global public health emergency. WHO leaders did call for an escalated response, including more support from UN peacekeeping forces, to halt the virus' spread.
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