The devastating effects of Zika virus are becoming evident as those born with related defects in Brazil grow older, and now more cases of microcephaly are surfacing among infants in Angola. The data emphasize the need for funding for continuous surveillance, monitoring and prevention of the disease, as well as the need for improved diagnostics and birth defect monitoring programs.
The World Health Organization declared that the Democratic Republic of Congo's current Ebola outbreak does not constitute a global public health emergency. WHO leaders did call for an escalated response, including more support from UN peacekeeping forces, to halt the virus' spread.
Research led by Oregon Health & Science University scientists has yielded the largest acute myeloid leukemia dataset yet, consisting of 672 samples from 562 patients, and they hope the work will lead to new advances in AML care. The team developed a novel data visualization system known as Vizome to organize the information, and the work is described in the journal Nature.
A National Cancer Patient Experience Survey in the UK showed that 59% of patients with hematologic cancers said they fully understood their diagnosis after receiving it, substantially less than for skin, prostate and colorectal cancers. "If people do not understand their diagnosis, then they are not in a position to ask informed questions about their condition or to explain their disease to their loved ones," said Sarah Porch of the British charity Bloodwise.
Zipline currently meets 30% of Rwanda's national demand for emergency transfusions by delivering blood and other supplies to outlying clinics via drone, and an expanded agreement will allow the company to supply the rest of the country. Zipline is testing a similar system in Ghana and working on a pilot project in North Carolina as well.
Spanish researchers assessed reservoir reductions in 23 patients with HIV-1 infections and high-risk hematologic disease who had been treated with antiretroviral therapy and allogeneic hematopoietic stem cell transplant. Findings published in the journal Annals of Internal Medicine indicated that allo-HSCT induces long-term reduction in detectable HIV with ongoing ART.
The American Red Cross has partnered with the Sickle Cell Disease Association of America and the Sickle Cell Foundation of Georgia on a five-year collaboration to promote blood donation, particularly among African-Americans, among whom SCD is common.
Thirty-one papers from the lab of Dr. Piero Anversa, whose work explored use of cardiac stem cells for regeneration of heart tissue, contain "falsified and/or fabricated data" and should be retracted, according to Harvard Medical School and Brigham and Women's Hospital. Anversa had said the heart contains stem cells known as c-kit cells, but efforts to reproduce his findings failed, and studies that tested injection of c-kit cells into ailing hearts yielded mixed results.
Investigators found no significant difference in overall mortality rates at 90 days among 488 patients with severe acute kidney injury and septic shock who were assigned to either early strategy renal replacement therapy, involving treatment within 12 hours of failure-stage AKI diagnosis, or a delayed strategy, involving treatment after 48 hours if there was no renal recovery. The research was published in The New England Journal of Medicine.
The World Health Organization on Wednesday will convene an emergency meeting to discuss whether the most recent Ebola outbreak in the Democratic Republic of Congo should be designated a public health emergency of international concern. DRC officials report that 33 new infections have been confirmed over the last week, and 24 of those cases were fatal.
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