A midstage trial found maribavir treatment following transplants of hematopoietic stem cells or solid organs was comparable to treatment with valganciclovir for clearance of cytomegalovirus viremia, according to a study in The New England Journal of Medicine. The 159-patient midstage clinical trial found a higher rate of serious adverse events with maribavir than valganciclovir.
McKesson and TrakCel will collaborate to address cell and gene therapy supply chain challenges using data management software from TrakCel and McKesson's patient services.
Emmaus Life Sciences withdrew its marketing application for the sickle cell disease drug Xyndari, or glutamine, after it received a negative opinion from the Committee for Medicinal Products for Human Use, the advisory group of the European Medicines Agency.
Researchers found that exposure to a slightly altered Ebola virus induced an immune response in monkeys that protected them from the parent virus, according to a study in the journal Cell Reports. The goal is to produce a drug that knocks out the VP35 protein in the Ebola virus, although researchers cautioned that it may not have the same effect in humans as in animals.
Inovio Pharmaceuticals is the recipient of a $4.6M grant from the NIH that it will use to advance research on antimicrobial resistance with the use of its DNA-encoded monoclonal antibodies scaffold. The funding will support preclinical studies to be launched as clinical trials to assess dMAbs for infections resistant to antimicrobials.
A position statement from AACC says clinical laboratories have an important role in fighting the opioid epidemic, and the group is urging a multidisciplinary, team-based approach to the epidemic with more collaboration among clinical laboratories, law enforcement agencies and public health officials. "Leveraging the expertise of clinical laboratory professionals to identify the use of synthetic opioids can help clinicians and first responders make informed treatment decisions and help public health and safety officials identify the cause of overdose outbreaks and coordinate a response," the position statement says.
A study found nondaily pre-exposure prophylaxis use among men in the US resulted in decreased efficacy compared with daily usage. Further studies of effectiveness are needed to guide recommendations, the study team wrote in the journal Clinical Infectious Diseases.
The World Health Organization said its funds for responding to Ebola virus infection in the Democratic Republic of Congo may not be enough to sustain operations through the end of the year. Meanwhile, the number of new weekly cases in two hard-hit provinces was the lowest since March.
Natera's Evercord cord blood and tissue banking unit is being sold to CBR, which is owned by California Cryobank Life Sciences. Natera said it will focus on its core business of genetic testing.
Kenya will begin rolling out a routine malaria immunization for children younger than 2 in eight of its 47 counties. Pilot immunization programs have also been started in Ghana and Malawi.
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