Lab Sciences
Top stories summarized by our editors
4/15/2019

A five-year, $22 million grant from the National Institute of Allergy and Infectious Diseases will support the international Prometheus Center for Excellence in Translational Research project, which aims to develop antibody-based therapies for viruses that spread from animals to humans. The target viruses are the Crimean-Congo hemorrhagic fever virus and the Andes, Puumala and Sin Nombre hantaviruses.

4/12/2019

A study published in the journal Blood found sickle cell disease affected the dynamics and structure of blood clots in tests of mice and human blood. Clots formed of sickle-shaped cells in the veins of the mice were denser and had more fibrin. Red blood cell exchange had a long-lasting effect on normalizing whole blood clot behavior.

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Blood
4/12/2019

Natera said it will offer whole exome sequencing of circulating tumor DNA found in the plasma of cancer patients as a service for use in research only. The service should be available in the second half of the year.

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Seeking Alpha
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Natera
4/10/2019

Myriad Genetics, AstraZeneca and Merck have agreed to expand their companion diagnostics collaboration, a move that will allow the companies to use Myriad's BRACAnalysis CDx to find germline BRCA mutations in men with metastatic castrate-resistant prostate cancer who are part of a late-stage trial. In the event of a successful trial, Myriad plans to submit a supplemental application to the FDA for approval to market the BRACAnalysis CDx as a companion diagnostic for Lynparza in men with mCRPC cancer.

4/10/2019

PerkinElmer has partnered with DNA testing startup Helix to launch GenePrism, a consumer gene testing product designed to analyze 59 genes deemed medically actionable by the American College of Medical Genetics and Genomics. Under the collaboration, Helix will be in charge of sequencing the user's DNA and results will be passed to PerkinElmer, which will be responsible for data analysis and interpretation.

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MedCity News
4/10/2019

A Series C financing round has pulled in $3.1 million for Inanovate, a life sciences firm specializing in blood tests for cancer and autoimmune diseases. The money will be used to expedite development of the company's breast cancer blood test.

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FinSMEs
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cancer
4/10/2019

A meta-analysis found that direct-acting oral anticoagulants were not superior to warfarin for treating acute venous thromboembolism but were associated with a lower rate of adverse drug events. The findings were reported in the journal PLOS ONE.

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warfarin, thromboembolism
4/9/2019

New York City Mayor Bill de Blasio's administration has declared a public health emergency and ordered mandatory measles vaccinations in some parts of the Williamsburg section of Brooklyn as nearly 300 people have contracted the disease. The order covers certain ZIP codes, halts school and day-care attendance for the unvaccinated and includes fines for those who resist the order.

4/9/2019

A study published in the journal Annals of Internal Medicine showed that patients who injected drugs and underwent directly observed hepatitis C therapy had higher adherence rates compared with those who had self-administered individual treatment. Overall adherence was 78% among the 158 participants, with overall sustained virologic response of 94% across both groups.

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HCV
4/9/2019

Following a 20% increase in Clinical Laboratory Improvement Amendments fees, AACC is urging the CMS to improve the program and resume laboratory inspections as part of its Certificate of Waiver project. Additionally, "AACC believes that the CLIA oversight structure for [laboratory-developed tests] is appropriate and would support reasonable evidence-based improvements within the confines of CLIA to address LDT concerns."

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CLIA