Uganda is launching a preventive Ebola virus vaccination campaign for about 2,100 health workers near the border with the Democratic Republic of Congo. Two new Ebola cases in the DRC city of Beni were reported Friday, bringing the total for the current outbreak to 287.
A study by the NIH and Brazil's Sao Paulo-Minas Gerais Tropical Medicine Research Center found that benznidazole treatment for chronic Chagas' disease was associated with decreased mortality, parasite counts and cardiomyopathy markers. The study was based on data for about 1,800 patients.
A Phase I/IIa study in the British Journal of Haematology found the compound DTP3, an inhibitor of the protein GADD45b and the enzyme MKK7, was associated with a halt of cancer progression in two of three patients. No complications were reported, and the patients completed their 28-day regimens.
TG Therapeutics announced that updated data will be presented at a December meeting for umbralisib/ublituximab as a treatment for patients with BTK-refractory chronic lymphocytic leukemia and treatment-resistant follicular lymphoma.
Researchers compared the cost-effectiveness of core-antigen testing with ribonucleic acid testing for hepatitis C infections and found the former was the more economical choice. The World Health Organization and the European Association for the Study of the Liver have backed core-antigen testing when cost must be considered.
At the annual meeting of the American Society of Tropical Medicine and Hygiene, several presentations were made providing new data on dengue vaccines being developed from modified dengue viruses, all of which indicated safety and immunogenicity. Presenters provided data on the tetravalent vaccines TV003 and TV005, which contain attenuated strains of dengue serotypes, and GlaxoSmithKline's vaccines that use inactivated dengue viruses given with adjuvants.
ViiV Healthcare, an HIV company backed by GlaxoSmithKline, presented updated data on its experimental two-drug injection consisting of cabotegravir and rilpivirine at the HIV Glasgow Drug Therapy conference in Scotland. Data showed the injection is capable of producing high viral suppression rates, long-term durability of virologic response and positive overall tolerability.
High-dose intravenous iron was associated with reduced need for erythropoiesis-stimulating agents to treat dialysis-related anemia in a randomized study of 1,093 patients. The research was reported in The New England Journal of Medicine and at a meeting of the American Society of Nephrology.
Kadmon Holdings announced that dosing has started in the midstage ROCKstar trial to evaluate KD025 as a treatment for adults with previously treated chronic graft-versus-host disease. The trial will involve 126 participants, and primary completion is expected in September 2020.
The CDC Clinical Standardization Programs aim to improve patient care by verifying and maintaining analytical performance parameters of laboratory tests, writes Krista Poynter, a CDC contract research chemist. This year, for the first time, CDC received funding from Congress specifically to improve diagnostic tests for hormones. The CDC CSP plan to use that money to add new programs, including the Accuracy-based Monitoring Program for routine laboratories, and new biomarkers, including parathyroid hormones, free thyroxine and free testosterone.