At the annual meeting of the American Society of Tropical Medicine and Hygiene, several presentations were made providing new data on dengue vaccines being developed from modified dengue viruses, all of which indicated safety and immunogenicity. Presenters provided data on the tetravalent vaccines TV003 and TV005, which contain attenuated strains of dengue serotypes, and GlaxoSmithKline's vaccines that use inactivated dengue viruses given with adjuvants.
ViiV Healthcare, an HIV company backed by GlaxoSmithKline, presented updated data on its experimental two-drug injection consisting of cabotegravir and rilpivirine at the HIV Glasgow Drug Therapy conference in Scotland. Data showed the injection is capable of producing high viral suppression rates, long-term durability of virologic response and positive overall tolerability.
High-dose intravenous iron was associated with reduced need for erythropoiesis-stimulating agents to treat dialysis-related anemia in a randomized study of 1,093 patients. The research was reported in The New England Journal of Medicine and at a meeting of the American Society of Nephrology.
Kadmon Holdings announced that dosing has started in the midstage ROCKstar trial to evaluate KD025 as a treatment for adults with previously treated chronic graft-versus-host disease. The trial will involve 126 participants, and primary completion is expected in September 2020.
The CDC Clinical Standardization Programs aim to improve patient care by verifying and maintaining analytical performance parameters of laboratory tests, writes Krista Poynter, a CDC contract research chemist. This year, for the first time, CDC received funding from Congress specifically to improve diagnostic tests for hormones. The CDC CSP plan to use that money to add new programs, including the Accuracy-based Monitoring Program for routine laboratories, and new biomarkers, including parathyroid hormones, free thyroxine and free testosterone.
The HemoType SC assay detected 99.5% of patients with hemoglobin defects and had a specificity higher than 99% in a multi-center trial with 587 patients. The findings were published in the American Journal of Hematology.
A study in The Pediatric Infectious Disease Journal found that in-utero HIV infection was associated with a sixfold higher risk of congenital cytomegalovirus infection compared with cases of HIV exposure but not infection. Researchers highlighted the importance of CMV screening for HIV-exposed infants, especially when mothers were not treated with antiretrovirals during pregnancy.
The Senate unanimously passed the Sickle Cell Disease Research, Surveillance, Prevention and Treatment Act, which will now go to the House. The legislation lets HHS make grants to support public health initiatives, treatment programs and data collection on the prevalence of the disease.
It's been two years since Florida had 1,600 cases of Zika virus infection, including 300 in Miami-Dade County, and the CDC has reported no cases of locally acquired infection in the US this year. Miami-Dade County's mosquito control director Bill Petrie, a zoologist, said Zika and dengue continue to circulate in the region even as the county has raised its mosquito-control budget to over $16 million from $1.6 million.
Investigators identified four single nucleotide polymorphisms associated with risk for warfarin-related bleeding among African-Americans. The findings were reported in the Journal of the American Medical Association.