A broadly acting antiviral, remdesivir, reduced the severity of Middle East respiratory syndrome and prevented coronavirus replication and lung damage in infected rhesus monkeys, and it prevented illness when administered prior to exposure, researchers report in Proceedings of the National Academy of Sciences. The drug could have similar effects against other coronaviruses, including the virus that causes COVID-19, but its developer and Chinese health authorities are reportedly struggling to recruit enough patients for a clinical trial.
Studying brain tissue immediately after brain surgery could yield insights that studying animal brains cannot, but "brain research in animal models is essential to provide experimentally testable systems to perform mechanistic studies, which is a fundamental limitation to human brain studies," says neuroscientist Ed Lein, who presented findings at an American Association for the Advancement of Science meeting. Studies on animals allow researchers to control variables in way that is impossible in human studies, said biomedical researcher Robin Lovell-Badge.
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A field safety notice for some lots of its Alaris extension sets has been issued by Becton Dickinson to customers in Europe, urging users to inspect and quarantine affected devices and destroy unused units. The company received reports about the risk of the device's male luer becoming disconnected from the female luer, which could result in medication leakage and therapy disruptions.
European regulators gave CE mark approval to Novacyt's novel coronavirus test, which was launched by its Primerdesign molecular division. The company has also submitted an emergency use authorization application to the FDA.
The Korea Ministry of Food and Drug Safety has approved Seegene's Allplex 2019-nCoV Assay for emergency use. The single-tube coronavirus assay, which has also received CE-IVD marking, can produce results within four hours.
Abbott is boosting the manufacturing capacity for its MitraClip, a transcatheter mitral valve repair device, while awaiting the CMS' national coverage determination. A national coverage analysis is expected to be completed by May 14.
Sanofi's Seprafilm Adhesion Barrier and its assets have been acquired by Baxter for $350 million. The device is used to reduce adhesions during abdominal and pelvic surgeries, and it is commercially available in several countries, including the US and China.
Grail's multi-cancer blood test will undergo an interventional trial, which will enroll 6,200 patients aged 50 and older. "We are partnering with leading healthcare systems to gain important real-world insight into the clinical use of our multi-cancer early detection test, an important step on our path toward commercialization," said Grail CEO Hans Bishop.
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