Using aerosolized antibiotics with ventilator-associated pneumonia patients can help avoid systemic antimicrobial exposure, but there remain drawbacks. In this interview, Michael E. Klepser from Ferris State University College of Pharmacy, in Big Rapids, Mich., says there is a risk for bacteremia in patients. "There's also considerable variation in the ability of different nebulizers to deliver a drug to the patient. As a result, each nebulizer–antibiotic combination may need to be evaluated to determine the stability and delivery characteristics," Klepser said.
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